Dopamine depletion in neonatal rats: effects on behavior and striatal dopamine release assessed by intracerebral microdialysis during adulthood
Identifieur interne : 004957 ( Main/Exploration ); précédent : 004956; suivant : 004958Dopamine depletion in neonatal rats: effects on behavior and striatal dopamine release assessed by intracerebral microdialysis during adulthood
Auteurs : Edward Castan Eda [Canada] ; Ian Q. Whishaw [Canada] ; Leonard Lermer [Canada] ; Terry E. Robinson [États-Unis]Source :
- Brain Research [ 0006-8993 ] ; 1990.
English descriptors
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Abstract
Abstract: Rats depleted of dopamine (DA) by intraventricular 6-hydroxydopamine (6-OHDA) in infancy show behavioral impairments as adults, but their basic sensory-motor functions and feeding abilities are intact; at least relative to the pronounced deficits seen in rats given similar v treatment in adulthood. Here we investigate whether presynaptic changes culminating in enhanced DA release are present in adult rats that received neonatal damage, and whether these are of a sufficient magnitude to contribute to the sparing of function. We used microdialysis in rats during the resting state, walking on a treadmill, and after a systemic injection of amphetamine. It was found that neonatal 6-OHDA produced a nearly complete (<1% of control) depletion of DA in postmortem tissue, but this was not accompanied by a comparable decline in the basal extracellular concentrations of DA, which were only reduced by 12–54% of control values. In contrast, the extracellular concentrations of DA metabolites were greatly reduced, reflecting the post-mortem tissue concentrations of DA. Nevertheless, neonatally depleted animals were markedly deficient in their ability to respond to an amphetamine challenge, both behaviorally and in their ability to further increase DA release. Thus, following neonatal DA depletion there appear to be extensive changes in the few remaining DA terminals that are sufficient to maintain relatively high extracellular (and presumably synaptic) concentrations of DA during the resting state, but the capacity of the remaining DA neurons to respond to increased demand is very limited. This presynaptic compensatory response may play a role in the sparing of behavioral function seen following neonatal damage.
Url:
DOI: 10.1016/0006-8993(90)91113-U
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Whishaw</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychology, University of Lethbridge, Lethbridge, Alta.</wicri:regionArea><wicri:noRegion>Alta.</wicri:noRegion></affiliation></author><author><name sortKey="Lermer, Leonard" sort="Lermer, Leonard" uniqKey="Lermer L" first="Leonard" last="Lermer">Leonard Lermer</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychology, University of Lethbridge, Lethbridge, Alta.</wicri:regionArea><wicri:noRegion>Alta.</wicri:noRegion></affiliation></author><author><name sortKey="Robinson, Terry E" sort="Robinson, Terry E" uniqKey="Robinson T" first="Terry E." last="Robinson">Terry E. Robinson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The University of Michigan, Ann Arbor, MI 48109</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="ISSN">0006-8993</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1990">1990</date><biblScope unit="volume">508</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="30">30</biblScope><biblScope unit="page" to="39">39</biblScope></imprint><idno type="ISSN">0006-8993</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>5-Hydroxyindoleacetic acid</term><term>6-Hydroxydopamine in infant rats</term><term>Amphetamine</term><term>Development</term><term>Dialysis</term><term>Dihydroxyphenylacetic acid</term><term>Dopamine release</term><term>Homovanillic acid</term><term>Locomotion</term><term>Noradrenaline</term><term>Recovery and sparing of function</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Rats depleted of dopamine (DA) by intraventricular 6-hydroxydopamine (6-OHDA) in infancy show behavioral impairments as adults, but their basic sensory-motor functions and feeding abilities are intact; at least relative to the pronounced deficits seen in rats given similar v treatment in adulthood. Here we investigate whether presynaptic changes culminating in enhanced DA release are present in adult rats that received neonatal damage, and whether these are of a sufficient magnitude to contribute to the sparing of function. We used microdialysis in rats during the resting state, walking on a treadmill, and after a systemic injection of amphetamine. It was found that neonatal 6-OHDA produced a nearly complete (<1% of control) depletion of DA in postmortem tissue, but this was not accompanied by a comparable decline in the basal extracellular concentrations of DA, which were only reduced by 12–54% of control values. In contrast, the extracellular concentrations of DA metabolites were greatly reduced, reflecting the post-mortem tissue concentrations of DA. Nevertheless, neonatally depleted animals were markedly deficient in their ability to respond to an amphetamine challenge, both behaviorally and in their ability to further increase DA release. Thus, following neonatal DA depletion there appear to be extensive changes in the few remaining DA terminals that are sufficient to maintain relatively high extracellular (and presumably synaptic) concentrations of DA during the resting state, but the capacity of the remaining DA neurons to respond to increased demand is very limited. This presynaptic compensatory response may play a role in the sparing of behavioral function seen following neonatal damage.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Michigan</li></region></list><tree><country name="Canada"><noRegion><name sortKey="Castan Eda, Edward" sort="Castan Eda, Edward" uniqKey="Castan Eda E" first="Edward" last="Castan Eda">Edward Castan Eda</name></noRegion><name sortKey="Lermer, Leonard" sort="Lermer, Leonard" uniqKey="Lermer L" first="Leonard" last="Lermer">Leonard Lermer</name><name sortKey="Whishaw, Ian Q" sort="Whishaw, Ian Q" uniqKey="Whishaw I" first="Ian Q." last="Whishaw">Ian Q. Whishaw</name></country><country name="États-Unis"><region name="Michigan"><name sortKey="Robinson, Terry E" sort="Robinson, Terry E" uniqKey="Robinson T" first="Terry E." last="Robinson">Terry E. Robinson</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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